ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19.

doi:10.1097/FPC.0000000000000436

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ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19.

Pharmacogenetics and genomics - 1 Oct 2021

Möhlendick Birte, Schönfelder Kristina, Breuckmann Katharina, Elsner Carina, Babel Nina, Balfanz Paul, Dahl Edgar, Dreher Michael, Fistera David, Herbstreit Frank, Hölzer Bodo, Koch Michael, Kohnle Matthias, Marx Nikolaus, Risse Joachim, Schmidt Karsten, Skrzypczyk Sarah, Sutharsan Sivagurunathan, Taube Christian, Westhoff Timm H, Jöckel Karl-Heinz, Dittmer Ulf, Siffert Winfried, Kribben Andreas

Abstract excerpt

OBJECTIVES: The RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Cell entry is mediated by the human angiotensin-converting enzyme II (ACE2). ACE2 and its close homolog angiotensin-converting enzyme I (ACE) are currently discussed candidate genes, in which single-nucleotide polymorphisms (SNPs) could alter binding or entry of SARS-CoV-2...

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PMID: 34001841
DOI: 10.1097/FPC.0000000000000436
PMCID: PMC8415730

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