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Article

Smoking, alcohol consumption, and age at onset of Huntington's disease: a Mendelian randomization study.

Parkinsonism & related disorders - 1 Apr 2022

Wang Mengmeng, Liu Dandan, Yang Song, Li Yun, Lian Xuegan

Abstract excerpt

BACKGROUND: Smoking and alcohol consumption have been associated with earlier age at onset (AAO) of Huntington's disease (HD) in observational studies. We conducted this Mendelian randomization (MR) study to evaluate whether these associations are causal. METHODS: We selected genetic instruments for lifetime smoking (n = 462,690) and alcohol consumption (n = 941,280) based on two large genome-wide association...

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Identifiers

PMID: 35299068
DOI: 10.1016/j.parkreldis.2022.02.013

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