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Article

Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects.

Molecular psychiatry - 1 Oct 2022

Topiwala A, Taschler B, Ebmeier K P, Smith S, Zhou H, Levey D F, Codd V, Samani N J, Gelernter J, Nichols T E, Burgess S

Abstract excerpt

Alcohol's impact on telomere length, a proposed marker of biological aging, is unclear. We performed the largest observational study to date (in n = 245,354 UK Biobank participants) and compared findings with Mendelian randomization (MR) estimates. Two-sample MR used data from 472,174 participants in a recent genome-wide association study (GWAS) of telomere length. Genetic variants were selected on the basis of...

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Alcohol Drinking
Ethanol
Genetics, Aging, and Longevity in Model Organisms
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 35879401
DOI: 10.1038/s41380-022-01690-9
PMCID: PMC9718662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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