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Article

Effect of Body Weight on Age at Onset in Huntington Disease

6 Jul 2021

Abstract excerpt

OBJECTIVE: Weight loss is associated with clinical progression in Huntington disease (HD), but whether body weight causally affects disease onset or progression is unknown. Therefore, we aimed to assess whether genetically determined variations in body weight are causally related to age at onset in HD. METHODS: Using data from different recent genome-wide association studies, we performed a 2-sample mendelian...

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PMID: 34250226
DOI: 10.1212/nxg.0000000000000603

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