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Article

Effect of Propeptide Mutations on the Directed Evolution of Rhizomucor miehei Lipase.

Protein and peptide letters - 1 Jan 2022

Wang Jue, Bai Rong, Wu Na, Zhang Yumin, Hu Lili

Abstract excerpt

BACKGROUND: A series of mutants of Rhizomucor miehei lipase (RML) screened through four rounds of directed evolution were studied. Mutants' triglyceride hydrolysis activity was assessed, and their genes were sequenced. Results showed that mutations in the propeptide can improve the activity of RML during evolution. Two parts of propeptide (wild-type and mutant) and mature region were connected by molecular...

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PMID: 35289250
DOI: 10.2174/0929866529666220314105130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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