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Article

Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2005

Segall Laura, Mezzetti Alessandra, Scanzano Rosemarie, Gargus J Jay, Purisima Enrico, Blostein Rhoda

Abstract excerpt

A number of missense mutations in the Na,K-ATPase alpha2 catalytic subunit have been identified in familial hemiplegic migraine with aura. Two alleles (L764P and W887R) showed loss-of-function, whereas a third (T345A) is fully functional but with altered Na,K-ATPase kinetics. This study describes two additional mutants, R689Q and M731T, originally identified by Vanmolkot et al. [Vanmolkot, K. R., et al. (2003)...

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Identifiers

PMID: 16037212
DOI: 10.1073/pnas.0504323102
PMCID: PMC1178013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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