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A hidden Markov model to estimate homozygous-by-descent probabilities associated with nested layers of ancestors.

Theoretical population biology - 1 Jun 2022

Druet Tom, Gautier Mathieu

Abstract excerpt

Inbreeding results from the mating of related individuals and has negative consequences because it brings together deleterious variants in one individual. Genomic estimates of the inbreeding coefficients are preferred to pedigree-based estimators as they measure the realized inbreeding levels and they are more robust to pedigree errors. Several methods identifying homozygous-by-descent (HBD) segments with hidden...

Topics

Genotype
Homozygote
Humans
Inbreeding
Pedigree
Polymorphism, Single Nucleotide
Probability

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35283174
DOI: 10.1016/j.tpb.2022.03.001

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