Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution.

Journal of virology - 22 Jul 2025

Foster Charles S P, Walker Gregory J, Jean Tyra, Wong Maureen, Brassil Levent, Isaacs Sonia R, Lyu Yonghui, Turville Stuart, Kelleher Anthony, Rawlinson William D

Abstract excerpt

Understanding viral evolutionary dynamics is crucial to pandemic responses, prediction of virus adaptation over time, and virus surveillance for public health strategies. Whole-genome sequencing (WGS) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has enabled fine-grained studies of virus evolution in the human population. Serial passaging in vitro offers a complementary controlled environment to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to SARS-CoV-2

Share to Serial Passage

Share to Spike Glycoprotein, Coronavirus

Share to Vero Cells

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 40488621
DOI: 10.1128/jvi.00363-25
PMCID: PMC12282192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution.PMID 40488621Read ↗

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolutionSemantic proximity Read ↗

The mutational dynamics of the SARS-CoV-2 virus in serial passages in vitro.Semantic proximity Read ↗

Collaboration Between Host and Viral Factors Shape SARS-CoV-2 EvolutionSemantic proximity Read ↗

Emergence of genomic diversity and recurrent mutations in SARS-CoV-2.Semantic proximity Read ↗

SARS-CoV-2 mutations acquired during serial passage in human cell lines are consistent with several of those found in recent natural SARS-CoV-2 variantsSemantic proximity Read ↗

Limited SARS-CoV-2 diversity within hosts and following passage in cell cultureSemantic proximity Read ↗

Convergent Evolution and Host-Limiting Impacts of SARS-CoV-2 Revealed by Cellular Experiments.Semantic proximity Read ↗

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2Semantic proximity Read ↗

Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection.Semantic proximity Read ↗

Evidence of SARS-CoV-2 convergent evolution in immunosuppressed patients treated with antiviral therapies.Semantic proximity Read ↗

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2.Semantic proximity Read ↗

Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to HumansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.