Article
Are the original SARS-CoV-2 novel mutants from in vitro culture able to escape the immune response?
Journal of medical virology - 1 Jul 2023
He Jun, Mei Qingmin, Peng Yousong, Xie Jiajia, Li Weiwei, Ding Chengchao, Jiang Chengcheng, Chen Qingqing, Wang Jing, Zhang Yuqing, Ni Shuangshuang, Yu Junling, Liu Tao, Yang Weifei, Gong Lei, Zhang Xiangyu, Yuan Yuan, Zhang Zhuhui, He Lan, He Hongliang, Sun Yong, Wu Jiabing, Liu Zhirong, Gao Yong
Abstract excerpt
Monitoring variations in the virus genome to understand the SARS-CoV-2 evolution and spread of the virus is extremely important. Seven early SARS-CoV-2 isolates in China were cultured in vitro and were analyzed for their viral infectivity through viral growth assay, tissue culture infectious dose (TCID50 ) assay, spike protein quantification, and next generation sequencing analysis, and the resultant mutations in...
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