Article
Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera.
Scientific reports - 21 Jul 2022
Brandolini Martina, Dirani Giorgio, Taddei Francesca, Zannoli Silvia, Denicolò Agnese, Arfilli Valentina, Battisti Arianna, Manera Martina, Mancini Andrea, Grumiro Laura, Marino Maria Michela, Gatti Giulia, Fantini Michela, Semprini Simona, Sambri Vittorio
Abstract excerpt
The ongoing evolution of SARS-CoV-2 and the emergence of new viral variants bearing specific escape mutations responsible for immune evasion from antibody neutralisation has required a more accurate characterisation of the immune response as one of the evolutive forces behind viral adaptation to a largely immunised human population. In this work, culturing in the presence of neutralising sera vigorously promoted...
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