Article
Lymphocyte Activation Gene 3 Single-Nucleotide Polymorphisms in Bone Marrow Failure Diseases.
Analytical cellular pathology (Amsterdam) - 1 Jan 2022
Sun Yingying, Cao Qiuying, Zhao Xiaoyu, Liu Chunyan, Shao Zonghong
Abstract excerpt
Introduction: Lymphocyte activation gene 3 (LAG3) is an inhibitory checkpoint protein expressed on activated T effector, T regulatory, and natural killer cells. The main function of LAG3 is the regulation of immune homeostasis. Several studies have suggested its role in malignant and autoimmune diseases. The objective of this study was to explore the association between LAG3 single-nucleotide polymorphisms (SNPs)...
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