Article
Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections.
Science (New York, N.Y.) - 25 Feb 2022
Stracy Mathew, Snitser Olga, Yelin Idan, Amer Yara, Parizade Miriam, Katz Rachel, Rimler Galit, Wolf Tamar, Herzel Esma, Koren Gideon, Kuint Jacob, Foxman Betsy, Chodick Gabriel, Shalev Varda, Kishony Roy
Abstract excerpt
Treatment of bacterial infections currently focuses on choosing an antibiotic that matches a pathogen's susceptibility, with less attention paid to the risk that even susceptibility-matched treatments can fail as a result of resistance emerging in response to treatment. Combining whole-genome sequencing of 1113 pre- and posttreatment bacterial isolates with machine-learning analysis of 140,349 urinary tract...
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