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Modelling the spatial dynamics of oncolytic virotherapy in the presence of virus-resistant tumour cells

6 Dec 2022

Abstract excerpt

Oncolytic virotherapy is a promising form of cancer treatment that uses native or genetically engineered viruses to target, infect and kill cancer cells. Unfortunately, this form of therapy is not effective in a substantial proportion of cancer patients, partly due to the occurrence of infection-resistant tumour cells. To shed new light on the mechanisms underlying therapeutic failure and to discover strategies...

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PMID: 36473017
DOI: 10.1371/journal.pcbi.1010076

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