Article
The impact of oophorectomy on survival from breast cancer in patients with CHEK2 mutations.
British journal of cancer - 1 Jul 2022
Tomiczek-Szwiec Joanna, Szwiec Marek, Falco Michal, Cybulski Cezary, Wokolorczyk Dominika, Jakubowska Anna, Gronwald Jacek, Stawicka Malgorzata, Godlewski Dariusz, Kilar Ewa, Marczyk Elzbieta, Siołek Monika, Wiśniowski Rafal, Haus Olga, Sibilski Robert, Bodnar Lubomir, Sun Ping, Narod Steven A, Lubinski Jan, Huzarski Tomasz
Abstract excerpt
BACKGROUND: To estimate the impact of oophorectomy and other treatments on the survival of breast cancer patients with a CHEK2 mutation. METHODS: Women with Stage I-III breast cancer who were treated at 17 hospitals in Poland were tested for four founder mutations in the CHEK2 gene. 974 women (10%) were positive for a CHEK2 mutation. Control patients without a CHEK2 mutation were selected from a database of...
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