Article
Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Sept 2024
Schreurs Maartje A C, Schmidt Marjanka K, Hollestelle Antoinette, Schaapveld Michael, van Asperen Christi J, Ausems Margreet G E M, van de Beek Irma, Broekema Marjoleine F, Margriet Collée J, van der Hout Annemieke H, van Kaam Kim J A F, Komdeur Fenne L, Mensenkamp Arjen R, Adank Muriel A, Hooning Maartje J
Abstract excerpt
PURPOSE: Female CHEK2 c.1100delC heterozygotes are eligible for additional breast surveillance because of an increased breast cancer risk. Increased risks for other cancers have been reported. We studied whether CHEK2 c.1100delC is associated with an increased risk for other cancers within these families. METHODS: Including 10,780 individuals from 609 families, we calculated standardized incidence rates (SIRs)...
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