Article

<i>In Vitro</i> Generation and Characterization of The Wu Syndrome Model That Causes Mental Retardation in Neural Cell Lines

2024-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Wu Syndrome, also known as X-Linked Wu Type Intellectual Developmental Disorder, is caused by a mutation in the GRIA3 (Glutamate Ionotropic Receptor AMPA Type Subunit 3) gene located at position 25 on the X chromosome. GRIA3 encodes iGluR3, a subunit of the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor, which plays a critical role in rapid excitatory synaptic transmission...

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Literature Corpus work: 7d7db04b-217a-57b3-8368-5c816ea8cd1f
DOI: 10.1101/2024.07.01.601494

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