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Article

Co-occurrence of CDKN2A/B and IFN-I homozygous deletions correlates with an immunosuppressive phenotype and poor prognosis in lung adenocarcinoma.

Molecular oncology - 1 Apr 2022

Peng Yuan, Chen Yonghong, Song Mengmeng, Zhang Xiaoyue, Li Pansong, Yu Xian, Huang Yusheng, Zhang Ni, Ji Liyan, Xia Lei, Xia Xuefeng, Yi Xin, Tan Benxu, Yang Zhenzhou

Abstract excerpt

Homozygous deletion (HD) of CDKN2A and CDKN2B (CDKN2A/BHD ) is the most frequent copy-number variation (CNV) in lung adenocarcinoma (LUAD). CDKN2A/BHD has been associated with poor outcomes in LUAD; however, the mechanisms of its prognostic effect remain unknown. We analyzed genome, transcriptome, and clinical data from 517 patients with LUAD from the Cancer Genome Atlas (TCGA) and from 788 primary LUAD tumor and...

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Identifiers

PMID: 35253368
DOI: 10.1002/1878-0261.13206
PMCID: PMC9019898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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