Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

24 Jun 2021

Abstract excerpt

Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CDKN2A gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-α, IFN-β…) that are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Medical Imaging and Pathology Studies
Share to Occupational and environmental lung diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34249754
DOI: 10.3389/fonc.2021.695770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for TherapyPMID 34249754Read ↗

Co-occurrence of CDKN2A/B and IFN-I homozygous deletions correlates with an immunosuppressive phenotype and poor prognosis in lung adenocarcinoma.Semantic proximity Read ↗

Integrated genomics point to immune vulnerabilities in pleural mesothelioma.Semantic proximity Read ↗

Integrated genomics identify novel immunotherapy targets for malignant mesotheliomaSemantic proximity Read ↗

Implications of P16/CDKN2A deletion in pleural mesotheliomasSemantic proximity Read ↗

Loss of CDKN2A at chromosome 9 has a poor clinical prognosis and promotes lung cancer progressionSemantic proximity Read ↗

Molecular Changes in Mesothelioma With an Impact on Prognosis and TreatmentSemantic proximity Read ↗

A Combination of MTAP and p16 Immunohistochemistry Can Substitute for CDKN2A Fluorescence In Situ Hybridization in Diagnosis and Prognosis of Pleural MesotheliomasSemantic proximity Read ↗

Usefulness of NF2 hemizygous loss detected by fluorescence in situ hybridization in diagnosing pleural mesothelioma in tissue and cytology material: A multi-institutional studySemantic proximity Read ↗

CDK9 as an Appealing Target for Therapeutic InterventionsSemantic proximity Read ↗

Prevailing homozygous deletion of interferon and defensin genes in human cancersSemantic proximity Read ↗

Global Gene Expression Profiling of Pleural Mesotheliomas: Overexpression of Aurora Kinases and <i>P16/CDKN2A</i> Deletion as Prognostic Factors and Critical Evaluation of Microarray-Based Prognostic PredictionSemantic proximity Read ↗

A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.