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Landscape of adenosine-to-inosine RNA recoding across human tissues

4 Mar 2022

Abstract excerpt

RNA editing by adenosine deaminases changes the information encoded in the mRNA from its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally distinct, protein isoforms and diversify the proteome. The functional importance of a few recoding sites has been appreciated for decades. However, systematic methods to uncover these sites perform poorly, and the full repertoire of...

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PMID: 35246538
DOI: 10.1038/s41467-022-28841-4

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