Article
Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations.
Proceedings of the National Academy of Sciences of the United States of America - 8 Mar 2022
Yang Zheng Fang, Panwar Pankaj, McFarlane Ciaran R, Tuinte Wietske E, Campiglio Marta, Van Petegem Filip
Abstract excerpt
SignificanceIon channels have evolved the ability to communicate with one another, either through protein-protein interactions, or indirectly via intermediate diffusible messenger molecules. In special cases, the channels are part of different membranes. In muscle tissue, the T-tubule membrane is in proximity to the sarcoplasmic reticulum, allowing communication between L-type calcium channels and ryanodine...
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