Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.

Diabetes - 1 Sept 1999

Mahalingam B, Cuesta-Munoz A, Davis E A, Matschinsky F M, Harrison R W, Weber I T

Abstract excerpt

Mutations in human glucokinase are implicated in the development of diabetes and hypoglycemia. Human glucokinase shares 54% identical amino acid residues with human brain hexokinase I. This similarity was used to model the structure of glucokinase by analogy to the crystal structure of brain hexokinase. Glucokinase was modeled with both its substrates, glucose and MgATP, to understand the effect of mutations. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucokinase

Share to Glucose

Share to Hyperglycemia

Share to Hypoglycemia

Share to Models, Molecular

Share to Protein Conformation

Source

Identifiers

PMID: 10480597
DOI: 10.2337/diabetes.48.9.1698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.PMID 10480597Read ↗

Identification and characterization of the ATP-binding site in human pancreatic glucokinase.Semantic proximity Read ↗

Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site.Semantic proximity Read ↗

Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.Semantic proximity Read ↗

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.Semantic proximity Read ↗

Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.Semantic proximity Read ↗

Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.Semantic proximity Read ↗

Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.Semantic proximity Read ↗

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.Semantic proximity Read ↗

Identification of a phosphate regulatory site and a low affinity binding site for glucose 6-phosphate in the N-terminal half of human brain hexokinase.Semantic proximity Read ↗

ATP-binding site of human brain hexokinase as studied by molecular modeling and site-directed mutagenesis.Semantic proximity Read ↗

Characterizing glucokinase variant mechanisms using a multiplexed abundance assaySemantic proximity Read ↗

Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.