Article
Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis.
PLoS genetics - 1 Jul 2020
Soncini Samantha R, Chandrashekarappa Dakshayini G, Augustine David A, Callahan Kenny P, O'Donnell Allyson F, Schmidt Martin C
Abstract excerpt
Yeast and fast-growing human tumor cells share metabolic similarities in that both cells use fermentation of glucose for energy and both are highly sensitive to the glucose analog 2-deoxyglucose. Spontaneous mutations in S. cerevisiae that conferred resistance to 2-deoxyglucose were identified by whole genome sequencing. Missense alleles of the HXK2, REG1, GLC7 and SNF1 genes were shown to confer significant...
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