Article
Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.
Human molecular genetics - 10 Oct 2022
Portilla-Fernandez Eliana, Klarin Derek, Hwang Shih-Jen, Biggs Mary L, Bis Joshua C, Weiss Stefan, Rospleszcz Susanne, Natarajan Pradeep, Hoffmann Udo, Rogers Ian S, Truong Quynh A, Völker Uwe, Dörr Marcus, Bülow Robin, Criqui Michael H, Allison Matthew, Ganesh Santhi K, Yao Jie, Waldenberger Melanie, Bamberg Fabian, Rice Kenneth M, Essers Jeroen, Kapteijn Daniek M C, van der Laan Sander W, de Knegt Rob J, Ghanbari Mohsen, Felix Janine F, Ikram M Arfan, Kavousi Maryam, Uitterlinden Andre G, Roks Anton J M, Danser A H Jan, Tsao Philip S, Damrauer Scott M, Guo Xiuqing, Rotter Jerome I, Psaty Bruce M, Kathiresan Sekar, Völzke Henry, Peters Annette, Johnson Craig, Strauch Konstantin, Meitinger Thomas, O'Donnell Christopher J, Dehghan Abbas
Abstract excerpt
Progressive dilation of the infrarenal aortic diameter is a consequence of the ageing process and is considered the main determinant of abdominal aortic aneurysm (AAA). We aimed to investigate the genetic and clinical determinants of abdominal aortic diameter (AAD). We conducted a meta-analysis of genome-wide association studies in 10 cohorts (n = 13 542) imputed to the 1000 Genome Project reference panel...
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