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Article

RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma

28 Feb 2022

Abstract excerpt

BACKGROUND: RBBP4 activates transcription by histone acetylation, but the partner histone acetyltransferases are unknown. Thus, we investigated the hypothesis that RBBP4 interacts with p300 in a complex in glioblastoma (GBM). METHODS: shRNA silencing of RBBP4 or p300 and RNAseq was used to identify genes co-regulated by RBBP4 and p300 in GBM43 patient-derived xenograft (PDX). RBBP4/p300 complex was demonstrated...

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Share to Genomics and Chromatin Dynamics
Share to Glioma Diagnosis and Treatment
Share to Histone Deacetylase Inhibitors Research

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PMID: 35231103
DOI: 10.1093/neuonc/noac051

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