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Article

Examining the role of mitochondrial genetic variation in nicotine dependence.

Psychiatry research - 1 Apr 2022

Giannoulis Stavroula V, Chenoweth Meghan J, Saquilayan Paulo, Tyndale Rachel F, Lerman Caryn, Kennedy James L, Zawertailo Laurie, Gonçalves Vanessa

Abstract excerpt

Nicotine dependence (ND) has a heritability rate of ∼50%, suggesting genetic factors contribute to underlying mechanisms. Here, we aimed to examine variants within both mtDNA and the nuclear genome to determine if mitochondrial genes are associated with ND. A total of 129 mtDNA SNPs and 1136 nuclear-encoded mitochondrial genes in a sample of N = 374 Caucasians were selected for analysis. Age of onset of first,...

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Share to DNA, Mitochondrial
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 35227992
DOI: 10.1016/j.psychres.2022.114452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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