Article
Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies.
Viruses - 24 Jan 2022
Jary Aude, Marot Stéphane, Faycal Antoine, Leon Sacha, Sayon Sophie, Zafilaza Karen, Ghidaoui Emna, Quoc Stéphanie Nguyen, Nemlaghi Safaa, Choquet Sylvain, Dres Martin, Pourcher Valérie, Calvez Vincent, Junot Helga, Marcelin Anne-Geneviève, Soulié Cathia
Abstract excerpt
We explored the molecular evolution of the spike gene after the administration of anti-spike monoclonal antibodies in patients with mild or moderate forms of COVID-19. Four out of the 13 patients acquired a mutation during follow-up; two mutations (G1204E and E406G) appeared as a mixture without clinical impact, while the Q493R mutation emerged in two patients (one receiving bamlanivimab and one receiving...
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