Article
Spike Protein Genetic Evolution in Patients at High Risk of Severe Coronavirus Disease 2019 Treated by Monoclonal Antibodies.
The Journal of infectious diseases - 15 May 2024
Leducq Valentin, Zafilaza Karen, Fauchois Antoine, Ghidaoui Emna, Sayon Sophie, Dorival Céline, Meledje Marie-Laure, Lusivika-Nzinga Clovis, Yordanov Youri, Martin-Blondel Guillaume, Carrat Fabrice, Marcelin Anne-Geneviève, Soulie Cathia
Abstract excerpt
BACKGROUND: High-risk patients, often immunocompromised and not responding to vaccine, continue to experience severe coronavirus disease 2019 (COVID-19) and death. Monoclonal antibodies (mAbs) were shown to be effective to prevent severe COVID-19 for these patients. Nevertheless, concerns about the emergence of resistance mutations were raised. METHODS: We conducted a multicentric prospective cohort study,...
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