Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Covalently Engineered Protein Minibinders with Enhanced Neutralization Efficacy against Escaping SARS-CoV-2 Variants

25 Feb 2022

Abstract excerpt

The rapid emergence and spread of escaping mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has significantly challenged our efforts in fighting against the COVID-19 pandemic. A broadly neutralizing reagent against these concerning variants is thus highly desirable for the prophylactic and therapeutic treatments of SARS-CoV-2 infection. We herein report a covalent engineering strategy on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to SARS-CoV-2 and COVID-19 Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35212528
DOI: 10.1021/jacs.1c11554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Covalently Engineered Protein Minibinders with Enhanced Neutralization Efficacy against Escaping SARS-CoV-2 VariantsPMID 35212528Read ↗

Multivalent designed proteins protect against SARS-CoV-2 variants of concernSemantic proximity Read ↗

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variantsSemantic proximity Read ↗

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in miceSemantic proximity Read ↗

Broad neutralizing nanobody against SARS-CoV-2 engineered from pre-designed synthetic librarySemantic proximity Read ↗

Allostery links hACE2 binding, pan-variant neutralisation and helical extension in the SARS-CoV-2 Spike proteinSemantic proximity Read ↗

Converting non-neutralizing SARS-CoV-2 antibodies targeting conserved epitopes into broad-spectrum inhibitors through receptor blockadeSemantic proximity Read ↗

Designing a broad-spectrum four-helix bundle targeting different strains of SARS-CoV-2 Spike Receptor Binding Domains with ACE2-like binding interfaceSemantic proximity Read ↗

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-viralsSemantic proximity Read ↗

De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variantsSemantic proximity Read ↗

Highly potent anti-SARS-CoV-2 multivalent DARPin therapeutic candidatesSemantic proximity Read ↗

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variantSemantic proximity Read ↗

Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.