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Article

Mouse hybrid genome mediates diverse brain phenotypes with the specificity of reciprocal crosses.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2022

Chou Ming-Yi, Appan Dhivya, Chang Kai-Wei, Chou Chih-Hsuan, Lin Chia-Yi, Gau Susan Shur-Fen, Huang Hsien-Sung

Abstract excerpt

Hybrid species have more genetic diversity than their parents. However, the impact of the hybrid genome of reciprocal crosses on brain function remains largely unknown. We performed behavioral, molecular, and neuronal analyses on C57BL/6J mice (B6), CAST/EiJ mice (CAST), and hybrid mice resulting from reciprocal crosses of the two strains, B6/CAST F1i and B6/CAST F1r, respectively. Hybrid mice displayed greater...

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PMID: 35199866
DOI: 10.1096/fj.202101624R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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