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Article

Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.

Signal transduction and targeted therapy - 23 Feb 2022

Jin Yu, Kang Yalin, Wang Minghuan, Wu Bili, Su Beibei, Yin Han, Tang Yang, Li Qianxia, Wei Wenjie, Mei Qi, Hu Guangyuan, Lukacs-Kornek Veronika, Li Jian, Wu Kongming, Yuan Xianglin, Wang Wei

Abstract excerpt

Tumor-associated macrophages have emerged as crucial factors for metastases. Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis (BM). However, the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer (NSCLC) remains elusive. Here, we purified cell lines with brain-metastatic tropism and employed a...

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Identifiers

PMID: 35194016
DOI: 10.1038/s41392-022-00872-9
PMCID: PMC8864012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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