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Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jul 2024

Tang Mengyi, Xu Mingxin, Wang Jian, Liu Ye, Liang Kun, Jin Yinuo, Duan Wenzhe, Xia Shengkai, Li Guohui, Chu Huiying, Liu Wenwen, Wang Qi

Abstract excerpt

Patients who have non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations are more prone to brain metastasis (BM) and poor prognosis. Previous studies showed that the tumor microenvironment of BM in these patients is immunosuppressed, as indicated by reduced T-cell abundance and activity, although the mechanism of this immunosuppression requires further study. This study shows...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38696655
DOI: 10.1002/advs.202306348
PMCID: PMC11234401

Genes

EGFR
IL11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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