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Article

The interaction between DNA methylation and single-nucleotide polymorphism in regulating the mRNA expression of CYP1A1, GSTP1 and GSTM1 in population.

Toxicology letters - 1 May 2026

Liu Aixiang, Shi Yuxin, Li Xin, Wu Miao, Zhao Tingyi, Wu Yingying, Xia Na, Zhang Hongmei

Abstract excerpt

While polycyclic aromatic hydrocarbon (PAH) exposure is widely known to influence the expression of metabolic enzyme genes, the roles of DNA methylation and single-nucleotide polymorphisms (SNPs) remain unclear. This study aimed to investigate the interplay between DNA methylation and SNPs on the mRNA expression of CYP1A1, GSTP1, and GSTM1. Participants were divided into the low- (n = 63) and high-exposure...

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Share to Cytochrome P-450 CYP1A1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41903599
DOI: 10.1016/j.toxlet.2026.111886

Genes

CYP1A1
GSTM1
GSTP1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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