Article
Cellular and immunological mechanisms influence host-adapted phenotypes in a vector-borne microparasite.
Proceedings. Biological sciences - 23 Feb 2022
Lin Yi-Pin, Tufts Danielle M, Combs Matthew, Dupuis Alan P, Marcinkiewicz Ashley L, Hirsbrunner Andrew D, Diaz Alexander J, Stout Jessica L, Blom Anna M, Strle Klemen, Davis April D, Kramer Laura D, Kolokotronis Sergios-Orestis, Diuk-Wasser Maria A
Abstract excerpt
Predicting pathogen emergence and spillover risk requires understanding the determinants of a pathogens' host range and the traits involved in host competence. While host competence is often considered a fixed species-specific trait, it may be variable if pathogens diversify across hosts. Balancing selection can lead to maintenance of pathogen polymorphisms (multiple-niche-polymorphism; MNP). The causative agent...
Topics
- Animals
- Borrelia burgdorferi
- Borrelia burgdorferi Group
- Host Adaptation
- Lyme Disease
- Peromyscus
- Phenotype