Article
A case of ganglioglioma grade 3 with H3 K27M mutation arising in the medial temporal lobe in an elderly patient.
Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Jun 2022
Fujii Yutaro, Hatae Ryusuke, Hata Nobuhiro, Suzuki Satoshi O, Sangatsuda Yuhei, Takigawa Kosuke, Funakoshi Yusuke, Fujioka Yutaka, Kuga Daisuke, Mizoguchi Masahiro, Iwaki Toru, Yoshimoto Koji
Abstract excerpt
The mutation p.K27M in H3F3A (H3 K27M mutation) is mainly detected in diffuse midline glioma. However, recent studies have demonstrated that H3 K27M mutation could also be observed in a subset of gangliogliomas. Importantly, most H3 K27-mutated ganglioglioma cases also harbor BRAF V600E mutation. Herein, we report a rare case of H3 K27M-mutated ganglioglioma grade 3 without BRAF mutation arising in the medial...
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