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Article

Role of the HLA-G immune checkpoint molecule in pregnancy.

Human immunology - 1 May 2021

Rouas-Freiss Nathalie, Moreau Philippe, LeMaoult Joel, Papp Bela, Tronik-Le Roux Diana, Carosella Edgardo D

Abstract excerpt

The non-classical HLA class I molecule HLA-G is expressed in trophoblasts where it contributes to maternal-fetal tolerance. HLA-G has been implicated in the control of trophoblast invasion, uterine vascular remodeling, and maintenance of a local immunosuppressive state. Understanding HLA-G biology at the maternal-fetal interface is therefore a critical issue in reproduction. In this regard, we review here: (i)...

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Source

Identifiers

PMID: 33745758
DOI: 10.1016/j.humimm.2021.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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