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Article

Implications of ESR1 Mutations in Hormone Receptor-Positive Breast Cancer.

Current treatment options in oncology - 17 Apr 2018

Reinert Tomás, Gonçalves Rodrigo, Bines José

Abstract excerpt

OPINION STATEMENT: Endocrine treatment resistance eventually develops during adjuvant and even more often during hormonal treatment for advanced breast cancer (ABC). An ESR1 gene mutation, which encodes for the estrogen receptor (ER) protein, is one of the potential mechanisms of therapy resistance. The ESR1 mutations result in conformational changes in the ER leading to subsequent estrogen-independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29666928
DOI: 10.1007/s11864-018-0542-0

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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