Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma.

doi:10.1093/bjs/znab460

Article

Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma.

The British journal of surgery - 24 Feb 2022

Silva Arnaldo N S, Saito Yuichi, Yoshikawa Takaki, Oshima Takashi, Hayden Jeremy D, Oosting Jan, Earle Sophie, Hewitt Lindsay C, Slaney Hayley L, Wright Alex, Inam Imran, Langley Ruth E, Allum William, Nankivell Matthew G, Hutchins Gordon, Cunningham David, Grabsch Heike I

Abstract excerpt

BACKGROUND: Patients with Epstein-Barr virus-positive gastric cancers or those with microsatellite instability appear to have a favourable prognosis. However, the prognostic value of the chromosomal status (chromosome-stable (CS) versus chromosomal instable (CIN)) remains unclear in gastric cancer. METHODS: Gene copy number aberrations (CNAs) were determined in 16 CIN-associated genes in a retrospective study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Dosage

Share to Genes, p53

Share to Herpesvirus 4, Human

Share to Immunocompromised Host

Share to Neoplasm Staging

Share to Stomach Neoplasms

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma.PMID 35179206Read

Chromosomal copy number based stratification of gastric cancer has added prognostic value to Lauren’s histological classificationSemantic proximity Read

Clinical significance of chromosomal integrity in gastric cancers.Semantic proximity Read

Chromosomal instability as a prognostic marker in cervical cancerSemantic proximity Read

c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal CancerSemantic proximity Read

p53 immunostaining cannot be used to predict TP53 mutations in gastric cancer: results from a large Central European cohort.Semantic proximity Read

Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and TherapySemantic proximity Read

Chromosomal Instability in Gastric Cancer BiologySemantic proximity Read

Molecular Landscape and Clinical Implication of CCNE1-amplified Esophagogastric Cancer.Semantic proximity Read