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Article

Molecular Landscape and Clinical Implication of CCNE1-amplified Esophagogastric Cancer.

Cancer research communications - 3 Jun 2024

Rustgi Naryan, Wu Sharon, Samec Timothy, Walker Phillip, Xiu Joanne, Lou Emil, Goel Sanjay, Saeed Anwaar, Moy Ryan H

Abstract excerpt

Cyclin E overexpression as a result of CCNE1 amplification is a critical driver of genomic instability in gastric cancer, but its clinical implication is largely unknown. Thus, we integrated genomic, transcriptomic, and immune profiling analysis of 7,083 esophagogastric tumors and investigated the impact of CCNE1 amplification on molecular features and treatment outcomes. We identified CCNE1 amplification in 6.2%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38717153
DOI: 10.1158/2767-9764.CRC-23-0496
PMCID: PMC11146286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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