Article
Immune signatures of prodromal multiple sclerosis in monozygotic twins.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2020
Gerdes Lisa Ann, Janoschka Claudia, Eveslage Maria, Mannig Bianca, Wirth Timo, Schulte-Mecklenbeck Andreas, Lauks Sarah, Glau Laura, Gross Catharina C, Tolosa Eva, Flierl-Hecht Andrea, Ertl-Wagner Birgit, Barkhof Frederik, Meuth Sven G, Kümpfel Tania, Wiendl Heinz, Hohlfeld Reinhard, Klotz Luisa
Abstract excerpt
The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs clinically discordant for MS and searched for disease-related peripheral immune signatures in a systems biology...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.