Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infection clusters can elevate risk of diagnostic target failure for detection of SARS-CoV-2.

PloS one - 1 Jan 2022

Lopez Denise, Roberts Jill, Bourgeois Marie, Kootstra Joshua, Minnick Sharon, Black Allison, Mauss Joshua, Flores Nick

Abstract excerpt

The C29197T mutation is one of 4 point mutations known to cause N-gene target failure (NGTF) in the Xpert Xpress SARS-CoV-2 and Xpert Omni SARS-CoV-2 assays from Cepheid (Sunnyvale, CA). We describe a high local prevalence in January of 8.5% (CI 4.9-14.2%) for the C29197T mutation, which was over 3-fold higher than the prevalence estimated statewide in California during the same time frame, 2.5% (CI 2.1-2.8%)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Prevalence
Share to COVID-19
Share to COVID-19 Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Molecular Diagnostic Techniques

Share to Phylogeny

Share to SARS-CoV-2

Share to Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 35171960
DOI: 10.1371/journal.pone.0264008
PMCID: PMC8849547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infection clusters can elevate risk of diagnostic target failure for detection of SARS-CoV-2.PMID 35171960Read ↗

Endemic SARS-CoV-2 Polymorphisms Can Cause a Higher Diagnostic Target Failure Rate than Estimated by Aggregate Global Sequencing DataSemantic proximity Read ↗

SARS-CoV-2 N Gene G29195T Point Mutation May Affect Diagnostic Reverse Transcription-PCR DetectionSemantic proximity Read ↗

Nucleocapsid single point-mutation associated with drop-out on RT-PCR assay for SARS-CoV-2 detection.Semantic proximity Read ↗

Validation of Reduced S-gene Target Performance and Failure for Rapid Surveillance of SARS-CoV-2 VariantsSemantic proximity Read ↗

Validation of reduced S-gene target performance and failure for rapid surveillance of SARS-CoV-2 variantsSemantic proximity Read ↗

Localised community circulation of SARS-CoV-2 viruses with an increased accumulation of single nucleotide polymorphisms that adversely affect the sensitivity of real-time reverse transcription assays targeting Nucleocapsid proteinSemantic proximity Read ↗

Impact of G29179T mutation on two commercial PCR assays for SARS-CoV-2 detection.Semantic proximity Read ↗

A recurrent mutation at position 26,340 of SARS-CoV-2 is associated with failure of the E-gene qRT-PCR utilised in a commercial dual-target diagnostic assaySemantic proximity Read ↗

SARS-CoV-2 N gene mutations impact detection by clinical molecular diagnostics: reports in two cities in the United States.Semantic proximity Read ↗

Mutations in emerging variant of concern lineages disrupt genomic sequencing of SARS-CoV-2 clinical specimensSemantic proximity Read ↗

A Recurrent Mutation at Position 26340 of SARS-CoV-2 Is Associated with Failure of the E Gene Quantitative Reverse Transcription-PCR Utilized in a Commercial Dual-Target Diagnostic Assay.Semantic proximity Read ↗

Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.