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Endemic SARS-CoV-2 Polymorphisms Can Cause a Higher Diagnostic Target Failure Rate than Estimated by Aggregate Global Sequencing Data

11 May 2021

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to mutate during the ongoing COVID-19 pandemic, and some of the nucleotide polymorphisms may result in diagnostic detection failures. Documented polymorphisms resulting in partial failure of diagnostic assays include g.26340C>T resulting in E gene target failure on the Roche (Indianapolis, IN) cobas 6800/8800 assay (1), g.21765_21770 deletion...

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PMID: 33972454
DOI: 10.1128/jcm.00913-21

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