Article
Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada.
Scientific reports - 27 Jun 2022
Isabel Sandra, Abdulnoor Mariana, Boissinot Karel, Isabel Marc R, de Borja Richard, Zuzarte Philip C, Sjaarda Calvin P, R Barker Kevin, Sheth Prameet M, Matukas Larissa M, Gubbay Jonathan B, McGeer Allison J, Mubareka Samira, Simpson Jared T, Fattouh Ramzi
Abstract excerpt
The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) was met with rapid development of robust molecular-based detection assays. Many SARS-CoV-2 molecular tests target multiple genetic regions of the virus to maximize detection and protect against diagnostic escape. Despite the relatively moderate mutational rate of SARS-CoV-2, numerous mutations with known negative impact on diagnostic...
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