Article
Real-Time RT-PCR Allelic Discrimination Assay for Detection of N501Y Mutation in the Spike Protein of SARS-CoV-2 Associated with B.1.1.7 Variant of Concern.
Microbiology spectrum - 23 Feb 2022
Abdulnoor Mariana, Eshaghi AliReza, Perusini Stephen J, Broukhanski George, Corbeil Antoine, Cronin Kirby, Fittipaldi Nahuel, Forbes Jessica D, Guthrie Jennifer L, Kus Julianne V, Li Ye, Majury Anna, Mallo Gustavo V, Mazzulli Tony, Melano Roberto G, Olsha Romy, Sullivan Ashleigh, Tran Vanessa, Patel Samir N, Allen Vanessa G, Gubbay Jonathan B
Abstract excerpt
The N501Y amino acid mutation caused by a single point substitution A23063T in the spike gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is possessed by three variants of concern (VOCs), B.1.1.7, B.1.351, and P.1. A rapid screening tool using this mutation is important for surveillance during the coronavirus disease 2019 (COVID-19) pandemic. We developed and validated a single nucleotide...
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