Article
Spike Gene Target Amplification in a Diagnostic Assay as a Marker for Public Health Monitoring of Emerging SARS-CoV-2 Variants - United States, November 2021-January 2023.
MMWR. Morbidity and mortality weekly report - 3 Feb 2023
Scobie Heather M, Ali Akilah R, Shirk Philip, Smith Zachary R, Paul Prabasaj, Paden Clinton R, Hassell Norman, Zheng Xiao-Yu, Lambrou Anastasia S, Kondor Rebecca, MacCannell Duncan, Thornburg Natalie J, Miller Joseph, Wentworth Dave, Silk Benjamin J
Abstract excerpt
Monitoring emerging SARS-CoV-2 lineages and their epidemiologic characteristics helps to inform public health decisions regarding vaccine policy, the use of therapeutics, and health care capacity. When the SARS-CoV-2 Alpha variant emerged in late 2020, a spike gene (S-gene) deletion (Δ69-70) in the N-terminal region, which might compensate for immune escape mutations that impair infectivity (1), resulted in...
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