Article
Mutation-Specific SARS-CoV-2 PCR Screen: Rapid and Accurate Detection of Variants of Concern and the Identification of a Newly Emerging Variant with Spike L452R Mutation.
Journal of clinical microbiology - 19 Jul 2021
Wang Huanyu, Jean Sophonie, Eltringham Richard, Madison John, Snyder Pamela, Tu Huolin, Jones Daniel M, Leber Amy L
Abstract excerpt
The emergence of more transmissible and/or more virulent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) has triggered intensive genomic surveillance, which is costly and difficult to sustain operationally over the long term. To address this problem, we developed a set of four multiplex mutation-specific PCR-based assays with same-day reporting that can detect five VOC and...
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