Article

Structure and computation-guided design of a mutation-integrated trimeric RBD candidate vaccine with broad neutralization against SARS-CoV-2

2021-06-18

Abstract excerpt

The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 is an attractive target for COVID-19 vaccine developments, which naturally exists in a trimeric form. Here, guided by structural and computational analyses, we present a mutation-integrated trimeric form of RBD (mutI tri-RBD) as a broadly protective vaccine candidate, in which three RBDs were individually grafted from three different circulating SAR...

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Literature Corpus work: 6e9a0c0b-2c6c-5e97-8f67-d35d2efc8aa6
DOI: 10.1101/2021.06.18.448958

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