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Article

Unfaithfulness and promiscuity of a mutant androgen receptor in a hormone-refractory prostate cancer.

Cellular and molecular life sciences : CMLS - 1 Feb 2006

Monge A, Jagla M, Lapouge G, Sasorith S, Cruchant M, Wurtz J-M, Jacqmin D, Bergerat J-P, Céraline J

Abstract excerpt

Missense mutations in the androgen receptor (AR) contribute to the failure of hormonal therapy for prostate cancer (PCa), but the underlying molecular bases remain uncharacterized. Here, we describe a new AR variant found in a hormone-refractory metastatic PCa, in which threonine 575 in the DNA binding domain, and threonine 877 in the ligand-binding domain, were both replaced by an alanine. Using gene reporter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16456618
DOI: 10.1007/s00018-005-5471-y
PMCID: PMC11136362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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