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Ribosomal DNA methylation in human and mouse oocytes increases with age

14 Feb 2022

Abstract excerpt

An age-dependent increase in ribosomal DNA (rDNA) methylation has been observed across a broad spectrum of somatic tissues and the male mammalian germline. Bisulfite pyrosequencing (BPS) was used to determine the methylation levels of the rDNA core promoter and the rDNA upstream control element (UCE) along with two oppositely genomically imprinted control genes (PEG3 and GTL2) in individual human germinal vesicle...

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PMID: 35157611
DOI: 10.18632/aging.203891

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