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Article

Aging alters histone H3 lysine 4 methylation in mouse germinal vesicle stage oocytes

2 Jan 2014

Abstract excerpt

Decreasing oocyte competence with maternal aging is a major factor in mammalian infertility. One of the factors contributing to this infertility is changes to chromatin modifications, such as histone acetylation in old MII stage oocytes. Recent studies indicate that changes in histone acetylation at MII arise at the germinal vesicle (GV) stage. We hypothesised that histone methylation could also change in old GV...

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PMID: 24384042
DOI: 10.1071/rd13293

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