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Article

DNA methylation analysis and editing in single mammalian oocytes

22 Apr 2019

Abstract excerpt

Significance Many mammalian nongenetic diseases and developmental disorders originate from oocyte DNA methylation abnormalities. However, prevention and correction of this maternally transmitted nongenetic disorder remains challenging because of the lack of strategy that can evaluate and manipulate specific methylation at single oocyte level. In this study, using several models of epigenetic inheritance via...

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Share to Epigenetics and DNA Methylation
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PMID: 31010926
DOI: 10.1073/pnas.1817703116

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